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NOVEL ANTICARCINOGENIC COMPOUNDS ISOLATED FROM ARTEMISIA CAPILLARIS

Bahn, Kyeong N. (Department of Agricultural Chemistry and Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University) , Lee, Eun J. (Department of Agricultural Chemistryand and Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University) , Lee, Jung M. (Department of Agricultural Chemistryand and Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University) , Byun, Jae I. (Department of Agricultural Chemistryand and Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University) , Park, Sook J. (Department of Agricultural Chemistryand and Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University) , Yang, Min S. (Department of Agricultural Chemistryand and Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University) , Ha, Yeong L. (Department of Agricultural Chemistryand and Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University)

Plant molecular biology and biotechnology research center Annual report, 1994, 1994, 329-335

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초록/요약moremore
Chloroform fraction of hot-methanol soluble materials from Artemisia capaillaris, which inhibited DMBA-induced mouse skin carcinogenesis (Bahn et al., 1993), was further fractionated into F1 fraction by combination of solvent partition and TLC procedures. From the F1 fraction exhibited a strong cytotoxicity (ED_(50):<0.08vg/ml) for both L1210 and S- 180 mouse cancer cells, achillin and its isomer were identified as the major anticarcinogenic compounds.
Chloroform fraction of hot-methanol soluble materials from Artemisia capaillaris, which inhibited DMBA-induced mouse skin carcinogenesis (Bahn et al., 1993), was further fractionated into F1 fraction by combination of solvent partition and TLC procedures. From the F1 fraction exhibited a strong cytotoxicity (ED_(50):<0.08vg/ml) for both L1210 and S- 180 mouse cancer cells, achillin and its isomer were identified as the major anticarcinogenic compounds.
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Ⅰ. Introduction = 329
Ⅱ. Results = 329
Ⅲ. Discussion = 334
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Ⅰ. Introduction = 329
Ⅱ. Results = 329
Ⅲ. Discussion = 334
Ⅳ. Summary = 335