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흰쥐에서 Cumambrin A의 대동맥 이완작용

Effect of Cumambrin A on the Relaxation of Rat Aorta,

홍용근 (Hong, Yong-Geun, 경상대학교 응용생명과학원, 자연과학대학 생명과학부 생화학과) , 양민석 (Yang, Min-Suk, 농업생명과학대학 환경생명화학과) , 박윤배 (Pak, Yun-Bae, 경상대학교 응용생명과학원, 자연과학대학 생명과학부 생화학과)

Plant molecular biology and biotechnology research center Annual report, 2005, 2005, 407-410

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We previously reported that the exogenous administration of cumambrin A, a sesquiterpene lactone from the dried flowers of Chrysanthemum boreale Makino has a pharmacological effect on normalization of blood pressure in the spontaneously hypertensive rats (SHR). In the present study, we further inves...
We previously reported that the exogenous administration of cumambrin A, a sesquiterpene lactone from the dried flowers of Chrysanthemum boreale Makino has a pharmacological effect on normalization of blood pressure in the spontaneously hypertensive rats (SHR). In the present study, we further investigated the effect of cumambrin A on the relaxation of phenylephrine-induced precontracted rat aortic artery rings. The potency of cumambrin A was then compared to verapamil, a well known Ca^(2+)-channel blocker. The results demonstrate that the isolated rat aortic arteries are relaxed to basal tension at a concentration of 5X10^(-5)M cumambrin A treatment. The results also show that the phenylephrine-induced contraction is inhibited by a pretreatment of cumambrin A. Co-treatment of cumambrin A and verapamil showed a strong synergetic effect on the relaxation of rat aortic artery rings. Thus, these data demonstrate that cumambrin A is a potent relaxant of rat aortic smooth muscle and suggest that cumambrin A modulates intracellular or extracellular Ca^(2+) mobilization.