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한국인의 만성 바이러스성 간염 및 간경변증환자에서 담낭 질환의 유병률에 관한 연구

Prevalence of Gallbladder Disease in Korean Patients With Chronic Viral Hepattitis And Cirrhosis,

정경아 (Jung, Kyoung Ah, 경상대학교 의과대학원)

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Background/Aim: Gallbladder stone is one of the major digestive diseases, and has a high morbidity in adults. In Korea, gallstone prevalence has reported about 2.2 to 3.5%. The risk factors of gallbladder disease(GBD) related to gallstone are age, obesity, rapid weight loss, hypertriglyceridemia, di...
Background/Aim: Gallbladder stone is one of the major digestive diseases, and has a high morbidity in adults. In Korea, gallstone prevalence has reported about 2.2 to 3.5%. The risk factors of gallbladder disease(GBD) related to gallstone are age, obesity, rapid weight loss, hypertriglyceridemia, diabetes mellitus, women, smoking. Moreover, liver cirrhosis was well known for the risk factors of GBD. Some studies suggested that Hepatitis C virus infection facillitates gallstone formation. But, relationship between chronic viral hepatitis and GBD is not exactly known. The purpose of the present study is to compare with prevalence of GBD in chronic viral hepatitis C, chronic viral hepatitis B, and the cirrhosis patients who was progressed from viral hepatitis in long period. Methods: A retrospective analysis was made of patients who underwent abdominal ultrasonography in Gyeongsang National University Hospital from 2000 January to 2004 December for hepatitis C virus infection(420 patients) and hepatitis B virus infection(1,397 patients). Patients were divided into chronic viral hepatitis and cirrhosis. As a control group, a total of 1,042 persons undergoing routine health screening were enrolled. Gallbladder disease was defined as ultrasound-documented gallstones or evidence of cholecystectomy. Results: The 12.1% (41/338 persons) among chronic viral hepatitis C had a GBD, and this was significantly higher prevalence than 4.9% (51/1,042 persons) in control group(P<0.001). The odds of GBD (Male=3.840, Female=1.671) among chronic viral hepatitis C was significantly higher compared with control. In chronic viral hepatitis B, prevalence of GBD was 9.1% (48/526 persons)(P=0.001). The prevalence of GBD was 20.7% in Anti-HCV positive cirrhotics, 19.7% in HBsAg-positive cirrhotics, and 33% in alcoholic cirrhosis patients. Conclusion: In chronic viral hepatitis patients, prevalence of GBD was significantly higher than control group and GBD was much more development in chronic viral hepatitis C. Chronic viral hepatitis as well as cirrhosis is considered as risk factor of GBD.
목차moremore
Ⅰ. 서 론 1
Ⅱ. 연구 대상 및 방법 3
1. 연구 대상 3
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Ⅰ. 서 론 1
Ⅱ. 연구 대상 및 방법 3
1. 연구 대상 3
2. 연구 방법 4
3. 통계적 분석 6
Ⅲ. 결 과 7
Ⅳ. 고 찰 11
Ⅴ. 참고문헌 17